Mounting internal Labour Party pressure after heavy losses in the May 2026 local and devolved elections has prompted more than 90 MPs to urge Keir Starmer to resign or set an exit timetable, with Health Secretary Wes Streeting resigning and confirming he would stand in any contest. Greater Manchester Mayor Andy Burnham is contesting the Makerfield by-election on 18 June as a potential route into Parliament and a leadership bid, while Starmer states he will fight on and retains backing from over 150 MPs. A formal challenge requires the leader’s resignation or nominations from 20% of Labour MPs, after which party members vote; the outcome hinges on whether these thresholds are met before scheduled parliamentary events.