The San Francisco 49ers hold the top position in NFC West champion markets after opening the 2026 season at 4-0 with the league’s highest-scoring offense and a passer rating led by quarterback Brock Purdy. Their upcoming Week 5 matchup against the Seahawks represents a key early test that could widen or close the gap. The Seattle Seahawks sit second at 3-1, buoyed by the NFL’s stingiest defense in yards allowed and recent roster adjustments that have kept their secondary intact. The Los Angeles Rams at 2-2 remain within striking distance through a balanced but inconsistent attack, while the Arizona Cardinals at 1-3 trail significantly after multiple lopsided defeats. Injury management around players such as Nick Bosa and Leonard Williams continues to shape weekly preparation across the division.