US-Iran negotiations to end seven months of conflict center on the disposition of Iran’s remaining stockpile of uranium enriched to 60 percent, estimated by the IAEA at roughly 200-plus kilograms buried at damaged sites like Isfahan following 2025-2026 strikes. On October 7, Vice President JD Vance stated Iran must deliver a “meaningful” reduction in enrichment capacity for any final agreement, indicating possible flexibility from earlier zero-enrichment demands while maintaining calls for stockpile destruction or removal under IAEA monitoring. Iran has blocked inspectors from bombed facilities, leaving the exact surviving quantity and location unverified, and talks continue on dilution, transfer, or third-party options amid sanctions relief and Strait of Hormuz issues. Upcoming diplomatic meetings and any IAEA access could shift the timeline for US acquisition or verified elimination of the material.