Taylor Swift’s “Patient Zero,” the lead single from the Sept. 25, 2026 release of *The Life of a Showgirl: The Encore*, drove the first-week streaming surge through strong pre-release buzz, a high-profile MTV VMAs video premiere on Sept. 27 featuring Dakota Johnson and Colin Farrell, and Swift’s established fanbase momentum. The track earned 70.7 million global streams and 80,000 sales in its opening tracking week (Sept. 25–Oct. 1), topping the Billboard Global 200 while posting 34.5 million U.S. streams en route to a Hot 100 debut at No. 1. It also set Spotify records for the most-streamed song by a female artist in a single day in 2026. Limited-edition physical variants shipping Oct. 13 and ongoing radio adds could extend its trajectory, though first-week figures are already locked.