US and Iranian negotiators reached a tentative agreement in early October 2026 to extend a ceasefire by 60 days and open fresh talks on Iran’s nuclear program, with the disposition of Tehran’s estimated 440 kg stockpile of uranium enriched to 60% identified as an immediate priority. Much of this material, assessed by the IAEA as remaining largely intact beneath damaged sites such as Isfahan following 2025 US-Israeli strikes, has not been verified or accessed since inspectors were barred. Prior framework discussions referenced on-site down-blending under IAEA supervision followed by removal, though Iran has signaled resistance to transferring the stockpile abroad. Vice President JD Vance has linked any final resolution to meaningful curbs on Iran’s enrichment capacity, while negotiators weigh third-party options and verification mechanisms amid broader sanctions and regional issues. Upcoming technical talks within the 60-day window could clarify timelines or barriers to US acquisition.