The Los Angeles Rams hold a clear edge in the 2026 season series against the Arizona Cardinals, driven by stronger roster construction, continuity under Sean McVay, and recent head-to-head results. With Matthew Stafford, Kyren Williams, and defensive additions like Myles Garrett, the Rams enter at 2-2 and have won the prior three meetings, including a 37-20 victory in January. The Cardinals sit at 1-3 with Jacoby Brissett under center following Kyler Murray’s departure, a new coaching staff led by Mike LaFleur, and ongoing offensive line and defensive challenges. Their two matchups—one on the road October 18 and the return November 15—leave limited room for an Arizona sweep, aligning with trader consensus favoring the Rams to claim the series.