Rams hold a modest edge in the season series market amid their stronger overall roster depth and Sean McVay’s proven track record against NFC West foes, even after an uneven 2-2 start marked by injuries to Aaron Donald, Puka Nacua, and others. The Cardinals sit at 1-3 under first-year coach Mike LaFleur with Jacoby Brissett under center following Kyler Murray’s departure, limiting their ability to challenge consistently in the two scheduled meetings. Recent head-to-head results heavily favor Los Angeles, though Arizona’s Week 1 upset and both clubs’ injury situations introduce variance heading into the October 18 matchup at SoFi Stadium and the later return game.